![]() Hepatitis C virus (HCV) infection is considered as one of the most important global health problems approximately, 177.5 million persons are considered infected. ![]() HCV eradication is associated with a high incidence of QTc normalization. At a cutoff value of 2.108, FIB-4 score can predict prolonged QTc. Also, it is related to the degree of fibrosis and cirrhosis. HCV is associated with QTc prolongation even in patients with early chronic liver disease stages without significant fibrosis. Twenty-four patients of long QTc group sent ECGs after HCV eradication, and 19 patients (79%) showed QTc normalization. FIB-4 score value of 2.108 predicted prolonged QTc with a sensitivity of 63.2% and a specificity of 64.5% ( P, < 0.001). QTc interval was 417.76 ± 34.12 ms in patients with FIB-4 score ≥ 1.45 vs. There was significant higher proportion of Fibrosis 4 (FIB-4) ≥ 1.45 score in the prolonged QTc (77.2%) vs. ![]() ![]() 411.51 ± 32.89 ms in cirrhotic and non-cirrhotic patients, respectively ( P, 0.001). There was significant higher proportion of cirrhotic patients in the prolonged QTc group (31.6%) vs. The study included 874 HCV patients with early cirrhosis in Child’s class A, 57 (6.5%) patients had prolonged QT interval corrected (QTc). Hepatitis C virus (HCV) is a common disease in Egypt with a high socioeconomic burden and extra-hepatic manifestations as QT prolongation, but previous studies included mainly patients with advanced liver disease, so in this study, we aimed to delineate the prevalence of QT prolongation in early-stage HCV patients. ![]()
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